Endocrine Abstracts

Objectives: We investigated cardiovascular and all-cause mortality in patients who underwent gastrectomies for early gastric cancer (EGC), and analyzed the changes in metabolic parameters in these patients after surgery.Background: Bariatric surgery, including gastric banding and gastric bypass, effectively induces weight loss and resolves cardiovascular comorbidities in obese patients.Methods: 2477 patients who underwent gastrecto...

Prostate cancer have been most cause of cancer death to men in recent, but there are not effective treatments for this cancer. In growth of prostate cancer, steroid hormones such as androgen play a role in their growth and survival. However, endocrine disrupting chemicals (EDCs) intend to bind the hormone receptor and induce the abnormal hormone response. EDCs have potency to activate estrogen receptor (ER) and androgen receptor (AR) mediated signaling pathways, and they cause...

Atypical manifestations of hyperthyroidism include hematological, cardiovascular, dermatological manifestation. Especially single lineage abnormalities such as anemia (34%), leukopenia (5.8%), thrombocytopenia (3.3%) are reported, but pancytopenia is a rare presentation of hyperthyroidism. The suspected etiologic mechanisms include ineffective hematopoiesis, reduction in blood cell life span, autoimmune process, toxicity of thyroid hormone.We report a ca...

The class of endocrine disrupting chemicals (EDCs) is comprised of both naturally occurring and man-made compounds which are structurally similar or distinct to estrogen, and can interfere with the actions of an endogenous steroid hormone via estrogen receptors (ERs). Octylphenol (OP) is alkyl phenol chemical, which is considered to be a low-level endocrine disruptor owing to its tendency to mimic estrogen. It has been reported that triclosan can cause endocrine disruption and...

Endocrine disrupting chemicals (EDCs) have brougt the growing concern about the potential to interfere with the endocrine system and to cause health problems. Among EDCs, bisphenol A (BPA) and 1,1,1-trichloro-2,2-bis(4-methoxyphenol)-ethane (methoxychlor, MXC) can bind to estrogen receptors (ERs) and lead abnormality of ER depenent signaling pathways, resulting in human health problems such as dysfuction of reproduction and carcinogenesis. In this study, we investigated whethe...

Benzophenones are organic chemicals widely used as stabilizers to UV light irradiation in plastic surface coatings and food packaging. They have been known that their derivatives appear to have cytotoxic effects. 2-Hydroxy-4-methoxybenzophenone (Benzophenone-3, BP-3) and its metabolite, 2,4-dihydroxybenzophenone (Benzophenone-1, BP-1), are used mostly in the formulation of nail polishes, enamels, bath products, sunscreens and skin care products. In this study, the estrogenic e...

Objective - Sarcopenic phenotype is associated with the increased risk of insulin resistance and type 2 diabetes. We investigated the proportion of sarcopenia and sarcopenic obesity (SO) and their clinical characteristics in patients with newly diagnosed type 2 diabetes.Research design and methods - We conducted a cross-sectional analysis of 133 (75 men, 58 women) patients with newly diagnosed type 2 diabetes. All patients underwent a 75 g oral glucose t...

The metabolic features of Polycystic ovary syndrome (PCOS) can vary based on the definition used. The aim of this study is to compare the metabolic characteristics of PCOS according to the phenotypes from various diagnostic criteria and help to establish a optimal diagnostic criteria.Subjects with PCOS defined by the NIH criteria (n=494) and the Rotterdam criteria (n=568) and regular cycling non-hirsuite control women (n=1000) were r...

Insulin resistance is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of insulin resistance and inflammatory response. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and insulin resistance and inflammatory marker in obese women with PCOS and controls.We recruited 50 obese women with PCOS (age 25±5 years, BMI 27.5±2.3...

Objective: To evaluate the effects of free fatty acids (FFAs) on the regulation of plasma and adipose tissue mRNA adiponectin expression in lean and obese subjects.Methods: Seven obese men (31.3±1.1 kg/m2) and eight lean men (21.3±0.4 kg/m2) were studied. Subjects received an Intralipid 20% infusion over 180-min with sodium heparin. Blood sampling and abdominal subcutaneous adipose tissue biopsy were taken before and after...